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SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
USERS' SCORE
Good
Based on 25 Reviews
8.6
Supplement Facts
Serving Size: 1 Softgel
Amount Per Serving
%DV
Calories
7
Vitamin E (as dl-Alpha tocopheryl acetate)
68 mg
453%
Coenzyme Q10
100 mg
**
Top Medical Research Studies
9
CoQ-10 reduces mortality, improves capacity
Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis.
Study directly assesses CoQ-10 effects
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
Read More
9
CoQ10 protects against heart injury
Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4/NF-κB signaling and necroptosis in rats.
Direct evaluation of CoQ10's benefits
We explored the protective effects of Coenzyme Q10 (CoQ10) and its liposomal form on heart health, particularly in response to copper toxicity caused by copper sulfate (CuSO4). In this study, rats received daily doses of CuSO4 to induce heart injury, while some were also treated with CoQ10 or L-CoQ10 to see if these supplements could mitigate the damage.
The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.
Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.
Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
Read More
9
Coenzyme Q10 enhances heart failure outcomes
Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials.
Highly relevant to cardiovascular research
We explored the effectiveness of coenzyme Q10 in treating heart failure through a thorough analysis of various randomized controlled trials. Our investigation involved a comprehensive search across numerous databases, looking specifically for studies that focused on the impact of coenzyme Q10 on heart failure patients.
The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.
Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.
Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
Read More
Most Useful Reviews
9.5
Heart health boost
Excellent for cardiovascular disease. My senior parents have long been fans of this CoQ10 brand recommended by their doctor. It supports their heart health, especially after procedures like angioplasty and open-heart surgery. I've tried it myself when feeling stressed, and it provides a boost in energy and heart health that I can’t get from regular vitamins. Our family highly endorses this product, as it is better absorbed than standard CoQ10 forms.
Read More
8.8
Improved mood
I bought this for my grandfather, who was depressed and uncommunicative. After two weeks of taking one capsule daily, alongside alpha-lipoic acid, his mood improved significantly. He also noticed benefits for his wife with Alzheimer's. Many other remedies had failed, but this one truly works. I plan to order more, as it’s economical and effective for energy and fatigue!
Read More
9.5
Family essential
Coenzyme Q10 is my go-to supplement. It noticeably benefits my cardiovascular system and provides energy. After my grandfather's heart attack, it helped him recover, and our family has recommended it ever since. I felt its effects after dealing with COVID-19, as my stamina improved when training.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 10 Researches
8.3
9
CoQ10 protects against heart injury
Coenzyme Q10 and its liposomal form prevent copper cardiotoxicity by attenuating oxidative stress, TLR-4/NF-κB signaling and necroptosis in rats.
Direct evaluation of CoQ10's benefits
We explored the protective effects of Coenzyme Q10 (CoQ10) and its liposomal form on heart health, particularly in response to copper toxicity caused by copper sulfate (CuSO4). In this study, rats received daily doses of CuSO4 to induce heart injury, while some were also treated with CoQ10 or L-CoQ10 to see if these supplements could mitigate the damage.
The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.
Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
The results showed that CuSO4 led to elevated cardiac injury markers and increased oxidative stress, which is known to contribute to heart issues. However, the inclusion of CoQ10 and L-CoQ10 helped lower the levels of harmful markers, improve antioxidant capacity, and reduce inflammation. These supplements effectively restored balance and reduced signs of heart injury, highlighting their potential cardioprotective roles.
Overall, the findings suggest that CoQ10 could serve as a valuable defense for individuals at risk of copper toxicity, reinforcing its relevance in supporting cardiovascular health.
Read More
9
Coenzyme Q10 enhances heart failure outcomes
Efficacy and safety of coenzyme Q10 in heart failure: a meta-analysis of randomized controlled trials.
Highly relevant to cardiovascular research
We explored the effectiveness of coenzyme Q10 in treating heart failure through a thorough analysis of various randomized controlled trials. Our investigation involved a comprehensive search across numerous databases, looking specifically for studies that focused on the impact of coenzyme Q10 on heart failure patients.
The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.
Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
The findings were quite promising. We observed that coenzyme Q10 not only reduced the rate of all-cause mortality but also decreased hospitalizations due to heart failure. Improvements were noted in several key health metrics such as the New York Heart Association classification and brain natriuretic peptide levels. Furthermore, participants benefited from enhanced left ventricular ejection fraction and better performance on the six-minute walk test.
Importantly, these benefits were achieved without major adverse effects, suggesting that coenzyme Q10 could be a safe and effective option for those managing heart failure. Overall, our analysis indicates that coenzyme Q10 offers significant advantages for heart failure patients, enhancing their quality of life and potentially extending longevity.
Read More
9
CoQ-10 reduces mortality, improves capacity
Evaluating the efficacy of ubiquinol in heart failure patients: a systematic review and meta-analysis.
Study directly assesses CoQ-10 effects
We explored the effects of coenzyme Q10 (CoQ-10) on heart failure (HF) patients by analyzing past literature. Our systematic review examined studies from MEDLINE and the Cochrane Library, focusing on how CoQ-10 influences outcomes like HF-related mortality, exercise capacity, and left ventricular ejection fraction (LVEF).
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
The results from 16 studies showed some promising findings. CoQ-10 was found to significantly lower HF-related mortality by 40%, which is a notable benefit for patients. Additionally, we observed improvements in exercise capacity for those taking CoQ-10. However, when it came to the impact on LVEF, the results were not statistically significant. While there wasn’t a clear-cut improvement in LVEF, we acknowledge that this aspect needs further exploration to fully understand CoQ-10's potential.
In summary, CoQ-10 appears to be effective in reducing mortality rates and enhancing exercise capacity among heart failure patients. Nonetheless, the effect on LVEF is still uncertain and merits additional investigation.
Read More
9
Coenzyme Q10 improves heart health
Six-month supplementation with high dose coenzyme Q10 improves liver steatosis, endothelial, vascular and myocardial function in patients with metabolic-dysfunction associated steatotic liver disease: a randomized double-blind, placebo-controlled trial.
Addresses cardiovascular effects significantly
We conducted a thorough investigation into the effects of coenzyme Q10 on cardiovascular health in patients suffering from Metabolic Dysfunction Associated Steatotic Liver Disease (MASLD). In this well-structured study, we utilized a randomized double-blind approach, dividing sixty participants to receive either 240 mg of coenzyme Q10 or a placebo daily for six months.
Our findings revealed that those taking coenzyme Q10 experienced significant improvements in several cardiovascular and liver health markers. Specifically, we noted reduced liver fat and enhanced endothelial function, indicating healthier blood vessels. Measurements showed positive changes in their vascular and myocardial functions, which are critical indicators of heart health.
Conversely, patients in the placebo group did not show any improvement throughout the study period. The results were compelling, underscoring not only the potential of coenzyme Q10 in mitigating liver steatosis but also its role in significantly boosting cardiovascular health.
Overall, by the end of our six-month research period, we observed a marked connection between improvements in liver function and cardiovascular markers, suggesting that coenzyme Q10 might be a beneficial treatment for those grappling with MASLD and associated cardiovascular risks.
Our findings revealed that those taking coenzyme Q10 experienced significant improvements in several cardiovascular and liver health markers. Specifically, we noted reduced liver fat and enhanced endothelial function, indicating healthier blood vessels. Measurements showed positive changes in their vascular and myocardial functions, which are critical indicators of heart health.
Conversely, patients in the placebo group did not show any improvement throughout the study period. The results were compelling, underscoring not only the potential of coenzyme Q10 in mitigating liver steatosis but also its role in significantly boosting cardiovascular health.
Overall, by the end of our six-month research period, we observed a marked connection between improvements in liver function and cardiovascular markers, suggesting that coenzyme Q10 might be a beneficial treatment for those grappling with MASLD and associated cardiovascular risks.
Read More
9
CoQ10 aids in mitigating tissue damage
HISTOLOGICAL EFFECTS OF CO ENZYME Q10 ON DOXORUBICIN-INDUCED DEFICITS OF CARDIOPULMONARY AXIS IN WHITE ALBINO RATS.
CoQ10's effects in chemotherapy context
We aimed to understand how Coenzyme Q10 (CoQ10) might help counteract the damage caused by doxorubicin, a common chemotherapy drug known for its harmful side effects on the heart and lungs. To investigate this, we conducted a study involving 27 rats divided into three groups: one group received CoQ10, another received doxorubicin, and the last group received both.
At the end of the study, we examined the hearts and lungs of the rats. Our findings revealed that doxorubicin led to significant harm to the cellular structures in both organs, confirming the drug's cardiotoxic and pulmonary damaging effects. However, when CoQ10 was administered, it showed a promising ability to alleviate these adverse effects, almost restoring the normal appearance of the tissues.
In summary, our study suggests that CoQ10 could act as a protective agent, helping to maintain healthy lung and heart tissues in the context of doxorubicin treatment. This could potentially offer a valuable strategy for enhancing the safety and efficacy of chemotherapy regimens.
At the end of the study, we examined the hearts and lungs of the rats. Our findings revealed that doxorubicin led to significant harm to the cellular structures in both organs, confirming the drug's cardiotoxic and pulmonary damaging effects. However, when CoQ10 was administered, it showed a promising ability to alleviate these adverse effects, almost restoring the normal appearance of the tissues.
In summary, our study suggests that CoQ10 could act as a protective agent, helping to maintain healthy lung and heart tissues in the context of doxorubicin treatment. This could potentially offer a valuable strategy for enhancing the safety and efficacy of chemotherapy regimens.
Read More
User Reviews
USERS' SCORE
Good
Based on 25 Reviews
8.6
9.5
Heart health boost
Excellent for cardiovascular disease. My senior parents have long been fans of this CoQ10 brand recommended by their doctor. It supports their heart health, especially after procedures like angioplasty and open-heart surgery. I've tried it myself when feeling stressed, and it provides a boost in energy and heart health that I can’t get from regular vitamins. Our family highly endorses this product, as it is better absorbed than standard CoQ10 forms.
Read More
9.5
Family essential
Coenzyme Q10 is my go-to supplement. It noticeably benefits my cardiovascular system and provides energy. After my grandfather's heart attack, it helped him recover, and our family has recommended it ever since. I felt its effects after dealing with COVID-19, as my stamina improved when training.
Read More
9.5
Biomarker improvement
CoQ10 is great for cardiovascular disease. Despite no exercise, my health checks showed reduced triglycerides and cholesterol after taking it for six months. I’ve purchased it multiple times—it's definitely effective!
9.5
Boosts heart health
My parents highly endorse this brand of CoQ10 for managing cardiovascular disease. It's particularly beneficial for their heart health, especially given their medical histories. I’ve also noticed it provides a boost when my heart feels overworked. It's better absorbed than regular CoQ10, and I've always received it intact from iHerb.
Read More
9.5
Great product
I believe this CoQ10 product uniquely benefits cardiovascular health. Thank you for making it available.
